METHYLPHENIDATE is a mild central nervous system stimulant; the drug has similar pharmacological properties as the amphetamines, with predominantly central activity and minimal effects on the cardiovascular system. Although its exact mechanism of action is not known, METHYLPHENIDATE is thought to activate the brainstem arousal system, cortex, and subcortical structures including the thalamus to produce its stimulant effect.

It is effective in lethargic, melancholic depression. Can display a shorter onset of action that other antidepressants. It can be given simultaneously with SSRI’s to initiate a more rapid response and "get the patient moving" while the SSRI reaches effectiveness. Once the patient responds to methylphenidate it can be removed and the patient managed on SSRI alone.